In the year 2012 besides Tamil Nadu other southern states too did deceased donation transplants more frequently. An online organ sharing registry for deceased donation and transplantation is used by the states of Tamil Nadu and Kerala. Both these registries have been developed, implemented and maintained by MOHAN Foundation . However. National Organ and Tissue Transplant Organization (NOTTO) is a National level organization set up under Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India and only official organization.
Manipulation of iPSCs holds great promise for regenerative medicine. However, clinical trials of “cell transplantation”, that is a current main target of stem cell-based approach, have presented unsatisfactory results. Our study demonstrates a proof-of-concept that “organ bud transplantation” offers an alternative approach resulting in the generation of a 3D, vascularized organ. These results highlight the enormous therapeutic potential using in vitro grown organ bud transplantation for treating organ failure.
The liver is significantly active in metabolizing compounds and the major target for toxicity caused by drugs. Liver toxicity and alterations of hepatic physiology are frequently occurring reasons for preclinical failure during drug development. Prioritization of compounds based on human hepatotoxicity potential is currently a key unmet need in drug discovery. Current hepatocyte model systems include primary human hepatocytes harvested from cadavers, immortalized cell lines, hiPSC-derived hepatocyte-like cells and animal models. However, each of these model systems presents limitations in functionality, reproducibility, and/or availability. Our results represent the potential for predicting humanized profile of drug metabolism mimicking in vivo human physiology. Fully functioning hepatocytes differentiated from hiPSCs in liver bud will aid to assess the drug safety and efficacy for preclinical drug discovery, hepatotoxicity testing, and disease research.